Technical Bulletin

Research Trend
shRNA screens lead to major discoveries
Loss-of-function screening using shRNA libraries is a powerful way to identify genes involved in almost any biological process. Over the past decade, shRNA screens, both in vivo and in cell culture systems, have generated many important discoveries... Read More
Research Trend
Controlling when and where: Conditional and inducible gene expression
In the early days of engineered animal models, simple knockout and transgenic mice were used to examine gene function. Researchers began to dissect the roles of individual genes by studying phenotypes of mice lacking or overexpressing specific genes... Read More
Research Trend
Optogenetics: Light-control of genes, pathways, and cells
Optogenenetics refers to a family of techniques which allow modulation of biological processes using light. Over the past 12 years, optogenetics has revolutionized neuroscience and is now expanding to impact many fields of biology. There are now... Read More
Breaking News
CRISPR causes unexpected and widespread mutations in vivo
Nuclease-mediated genome editing, using TALEN or CRISPR/Cas9, has exploded onto the scene in recent years, with hundreds of research papers and patents being published. These technologies hold great promise for treating a wide range of diseases by... Read More
Latest Discovery
CRISPR-based unicellular computer
A major goal of synthetic biology is to design and build digital genetic circuits inside cells, effectively programming cellular functions. Achieved this could allow living cells to be engineered to perform decision-making tasks, similar to computer... Read More
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